Mect Corporation

Naokazu Sugiyama

Takayuki Ishii

Tomoya Ogawa

Mamoru Sugimoto

Masaaki Numata

Makoto Tanaka

Kenkichi Tomita

Ryoichi Osawa

Tae Yasunaga

Mariko Ishii

Nobuyuki Kibushi

Isao Suda

Makiko Kasano

Kenji Abiko

Shikoh Minagawa

Motoaki Goto

Hideo Mizu

Kinichi Saito

An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts, thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

Method for modulating the immune system

An anti-inflammatory drug comprising as the effective component at least one compound selected from the group consisting of colominic acid, partial hydrolysis products of colominic acid and pharmaceutically acceptable salts thereof. The drug is used as a drug for renal diseases, a drug for hepatitis, an immunomodulator and a drug for inhibiting the chemotaxis of neutrophil.

Methods for inhibiting the chemotaxis of neutrophils

Anti-inflammatory agent

Sodium N-acetylneuraminate trihydrate herein provided is represented by the following formula: ##STR1## The sodium N-acetylneuraminate trihydrate can be prepared, for instance, according to a method which comprises the steps of: dissolving sodium N-acetylneuraminate in water or in a mixture of water and an organic solvent; allowing the resulting solution to stand; precipitating and separating the resulting crystals of sodium N-acetylneuraminate.trihydrate; and then drying the separated crystals. The sodium N-acetylneuraminate trihydrate has very low hygroscopicity and hence can be handled without any difficulty in the form of powder.

Sodium N-acetylneuraminate trihydrate

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Houya, Japan

Naokazu Sugiyama