Japan Tobacco Inc.

Naohito Yamada

Hiroshi Kawakami

Takashi Matsuda

Hisashi Shinkai

Mitsuru Takahashi

Satoshi Okuda

Wataru Watanabe

Yuji Matsuzaki

Motohide Satoh

Hisateru Aramaki

Shuichi Wamaki

Kazunobu Yamataka

Shinichi Kiyonari

Akemi Nagao

Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity. A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification. The present invention also relates to a pharmaceutical composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; an integrase inhibitor, an antiviral agent, anti-HIV agent, and the like, which contains the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient; an anti-HIV composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and one or more other kinds of anti-HIV activity substances as active ingredients; an anti-HIV agent containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient, which is used for a multiple drug therapy with other anti-HIV agent(s), and the like.

4-oxoquinoline compound and use thereof as HIV integrase inhibitor

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Osaka, Japan

Naohito Yamada