Seikagaku Corporation

Toei Shinyaku Co., Ltd.

Tokyo University of Science Foundation

Naohito Ohno

Yoshiyuki Adachi

Masuro Motoi

Akitomo Motoi

Hiroshi Tamura

Yoichiro Iwakura

Daisuke Yamanaka

Ce Tang

Noriko Miura

Norihiko Ogura

The &#x3b2;-glucan-binding protein contains an amino acid sequence represented by SEQ ID NO: 1.

&#x3b2;-glucan-binding protein, &#x3b2;-glucan detection kit, artificial DNA, and bacterium

A &#x3b2;-1,6-glucanase mutant which is a mutant of &#x3b2;-1,6-glucanase (EC 3.2.1.75), wherein a Glu residue located at a position corresponding to Glu (E)-321 in SEQ ID NO: 1 is substituted by an amino acid residue X or a Glu (E) residue located at a position corresponding to each of Glu (E)-225 and Glu (E)-321 in SEQ ID NO: 1 is substituted by an amino acid residue X, wherein the amino acid residue (X) is selected from the group consisting of Gln (Q), Gly (G), Ala (A), Leu (L), Tyr (Y), Met (M), Ser (S), Asn (N), and His (H); and a method for measuring &#x3b2;-1,6-glucan, including measuring &#x3b2;-1,6-glucan bonded to the mutant.

&#x3b2;-1, 6-glucanase mutant, and method for measuring &#x3b2;-1, 6-glucan

A growth enhancer for, or a bacterium that belongs to the genusand that has a homology of 16S rDNA of 90% or higher withorincludes a &#x3b2;-glucan having a molecular weight of from 0.2 K to 50 K. A regulatory T-cell number increasing agent, a method of enhancing growth of a lactic acid bacterium, a method of increasing the number of regulatory T-cells, a method of evaluating a regulatory T-cell number increasing effect, and a method of evaluating a growth enhancing effect on a lactic acid bacterium are also provided.

Lactic acid bacterium growth enhancer, regulatory T-cell number increasing agent, method of enhancing growth of lactic acid bacterium, method of increasing number of regulatory T-cells, method of evaluating regulatory T-cell number increasing effect, and method of evaluating lactic acid growth enhancing effect

A hybridoma capable of producing a monoclonal antibody against dectin-1, and a monoclonal antibody which specifically reacts with dectin-1.

Hybridoma capable of producing anti-dectin-1 monoclonal antibody

A glucan extracted by oxidation treatment of microorganism cells belonging to the genusunder alkaline conditions; a glucan obtained by dissolving an aqueous solvent-insoluble fraction of the glucan in an aprotic polar solvent; a glucan obtained by dissolving the glucan in a urea solution; methods for obtaining the glucan; a method for measuring an amount of (1&#x2192;3)-&#x3b2;-D-glucan in a sample using the glucan; and a (1&#x2192;3)-&#x3b2;-D-glucan measuring kit containing the glucan.

Growing community of inventors

Tokyo, Japan

Naohito Ohno