Ajinomoto Co., Ltd.

Ajinomoto Co., Inc., Patent & Licensing Department

Naohiko Yasuda

Yasuo Irie

Hisao Iwagami

Kenzo Yokozeki

Konosuke Sano

Eiji Nakanishi

Hiroshi Shiragami

Chikahiko Eguchi

Koji Mitsugi

Masaru Okutsu

Fumihide Tamura

Michito Sumikawa

Toshiya Tanabe

Kazuhiko Yamada

Yoshiteru Hirose

Masaru Otani

Koji Toi

Fusayoshi Kakizaki

Yasuo Ariyoshi

Keizo Matsuda

Hideyuki Shirae

Ichiro Noda

Kazushi Togo

Chieko Ishijima

Shigeru Yamanaka

Toshihisa Kato

Hideomi Saito

Teruhiko Kagawa

Takehiko Ichikawa

Yukio Sasaki

Ichiro Takase

Teruaki Nakamiya

A process for converting uridines to 2&prime;,3&prime;-dideoxy-2&prime;,3&prime;-didehydrouridines by reacting acetic anhydride with a 2&prime;,3&prime;-0-alkoxymethylideneuridine intermediate.

Process for producing and purifying 2&prime;,3&prime;-dideoxynucleosides, and process for producing 2&prime;,3&prime;-dideoxy-2&prime;,3&prime;-didehydronucleosides

A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. the 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.

Process for purifying 2',3'-dideoxynucleosides

A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.

Process for producing and purifying 2',3'-dideoxynucleosides, and

A compound which is: ##STR1## wherein R may be 1 to 5 H, Cl, Br, F, C.sub.1 -C.sub.4 straight chain or branched alkyl, OH, or CF.sub.3.

Aromatic sulfonic acid salts of a proline derivative

The present invention relates to novel azetidinone derivatives of the general formula: ##STR1## where n is 0 or 2,

4-Methylsulfonyl-azetidinone derivatives

A 5-substituted-3-isoxazolecarboxylic acid derivative of the general formula: ##STR1## wherein X stands for a phenyl group, thienyl group, furyl group or pyridyl group, each of which optionally may carry at least one substituent group; R stands for a phenyl group or hydroxyphenyl group; and A stands for a group of the formula: ##STR2## wherein Y stands for ##STR3## in which the carbon atom with which the carboxyl group combines with the nitrogen atom in A, M stands for a hydrogen atom or a substituent group, and Z stands for a hydrogen atom, hydroxy group, acyloxy group, carbamoyloxy group, aromatic heterocycle thio group or aromatic nitrogen-containing heterocycle quaternary ammonium group, is disclosed along with methods for producing these compounds.

5-Substituted-3-isoxazolecarboxylic acid derivatives

The invention relates to imidazolecarboxylic acid derivatives of penicillins and cephalosporins, which are especially useful for the treatment of Pseudomonas aeruginosa-derived infections in humans and other animals.

Imidazolecarboxylic acid derivatives

A method of preparing sodium salts of an imidazoledicarboxylic acid derivative of a substituted cephalosporin represented by the general formula of ##STR1## where X is a radical selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, amino, mono- or dialkylamino, mono- or diarylamino, mono- or diaralkylamino, acylamino, sulfonic acid, nitro or heterocyclic group;

Method of preparing sodium salts of imidazoledicarboxylic acid

An imidazoledicarboxylic acid derivative having the following formula: ##STR1## wherein X is a group selected from the group consisting of hydrogen atom and hydroxyl group. The compounds are useful as antibiotics.

Imidazoledicarboxylic acid derivative

A reactive derivative of imidazolecarboxylic acid having the formula: ##STR1## is useful in preparing imidazoledicarboxylic acid derivatives of alpha-aminopenicillins and cephalosporins.

Compounds having the following formula: ##STR1## wherein X is a radical selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, methyl and amino.

Imidazoledicarboxylic acid substituted cephalosporin derivatives

2-Amino-(2)-thiazoline-4-carboxylic acid is prepared by dehydrochlorinating S-(.beta.-carboxy-.beta.-chloroethyl) isothiourea by adding it to an aqueous medium maintained at a pH ranging from 5.5 to 7.5 with an alkali.

Process for producing 2-amino-(2)-thiazoline-4-carboxylic acid

L-amino acids are produced by fermenting a hydantoin compound with Flavobacterium aminogenes or its enzymes.

Method for producing L-amino acid

A method for producing L-cysteine and/or L-cystine which comprises: A. holding 2-amino-thiazoline-4-carboxylic acid in an aqueous solution at a pH of 5 to 11 in the presence of an effective amount of enzyme produced by a microorganism; said enzyme being capable of converting the 2-amino-thiazoline-4-carboxylic acid to L-cysteine and/or L-cystine, and said microorganism being capable of growing in a medium containing 2-amino-thiazoline-4-carboxylic acid as a nitrogen source; and B. recovering the L-cysteine and/or L-cystine formed from said aqueous solution.

Growing community of inventors

Yokosuka, Japan

Naohiko Yasuda