Otsuka Pharmaceutical Company, Limited

Naohiko Kanai

Takayuki Yasutomi

Ryosuke Hirota

Noriyuki Koyama

Minoru Okada

Yoshihiro Murakami

Hitoshi Matsushita

Yohei Yuki

Kengo Matsumoto

Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5)

Oxazole compound crystal

Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles 2&#x3b8;(&#xb0;) of 9.6&#xb1;0.2, 19.1&#xb1;0.2, and 21.2&#xb1;0.2 in an X-ray powder diffraction pattern measured using CuK&#x3b1; characteristic X-rays.

An ointment is provided. The ointment stably comprises an oxazole compound that has specific inhibitory activity against PDE4 and that is represented by the following formula (11). The ointment can be efficiently absorbed into the skin. 

Ointment containing an oxazole compound

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Osaka, Japan

Naohiko Kanai