J-pharma Co., Ltd.

Nippon Chemiphar Co., Ltd.

Dethree Res. Lab. Inc.

Naohiko Anzai

Hitoshi Endou

Daisuke Saito

Kunio Kobayashi

Michael Fitzpatrick Wempe

Tsuyoshi Endo

Masuharu Hirano

Hiroto Tanaka

Promsuk Jutabha

Jean-Francois Peyron

Hirano Masuharu

A method for treating cancer includes administering to a subject in need of the treatment an anticancer agent composition that includes the following agents as active ingredients; a LAT1 inhibitor, and one or more agents selected from the group consisting of an alkylating agent, a platinum-based antineoplastic agent, an anti-metabolite, a topoisomerase inhibitor, an anti-microtubule polymerizing agent, a hormonal agent, an anti-microtubule depolymerizing agent, an anticancer antibiotic, and a molecular targeted agent.

Anticancer agent composition

Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia. (In the Formula (III), R, R, R, and Rrepresent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or a cyano group, Rand Rform a benzene ring or a 5-membered heteroaryl ring containing 1 to 3 heteroatoms, as a ring constituent element, selected from nitrogen atoms, oxygen atoms, and sulfur atoms together with two carbon atoms to which Rand Rare bonded, Rand Rform a benzene ring together with two carbon atoms to which Rand Rare bonded or represent any of the groups represented by Rdescribed above, Wrepresents CRor N, and where, Rrepresents any of the groups represented by R, Xrepresents an oxygen atom or a sulfur atom, Yrepresents an alkylene chain having 1 to 8 carbon atoms, and where, the alkylene chain may be substituted with an alkyl group having 1 to 8 carbon atoms and the alkylene chain may be a linear or branched alkylene chain, the branched alkylene chain may have a 3- to 7-membered ring formed by side chains bonded to carbon atoms which are the same as or different from each other, together with the carbon atoms to which the side chains are bonded and may have a double bond in the middle thereof, and Zrepresents COH). 

URAT1 inhibitor

Growing community of inventors

Tokyo, Japan

Naohiko Anzai