Otsuka Pharmaceutical Company, Limited

Naohide Kanemoto

Seiji Sato

Kuninori Tai

Yohji Sakurai

Shigekazu Fujita

Takashi Okamoto

Tae Fukushima

Motohiro Itotani

Satoshi Matsuda

Toshio Shinohara

Chiharu Matsumura

This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.

Cyanotriazole compounds

Growing community of inventors

Osaka, Japan

Naohide Kanemoto