Nippon Steel Sumitomo Metal Corporation

Sumitomo Pharma Co., Ltd.

Nippon Steel Corporation

Sumitomo Dainippon Pharma Co., Ltd.

Kabushiki Kaisha Yaskawa Denki

Sumitomo Metal Industries, Inc.

Boston Biomedical, Inc.

Sumitomo Pipe & Tube Co., Ltd.

Nippon Steel & Sumikin Pipe Co., Ltd.

Naoaki Shimada

Atsushi Tomizawa

Wataru Hirose

Hitoshi Ban

Seiji Kamioka

Michitaka Yoshida

Nobusato Kojima

Shinjiro Kuwayama

Saburo Inoue

Akihiko Arakawa

Kazuto Yamazaki

Kenjiro Hira

Nobuhiro Okada

Chiang Jia Li

Manabu Okahisa

Wei Li

Kazuya Ishii

Toyomitsu Nakamura

Takashi Suyama

Yusuke Kinoshita

David Leggett

Tamotsu Toki

Kazuhito Imai

Hiroki Umehara

Toshihiko Sone

Makoto Matsuoka

Kento Hayashi

Yoshihiro Serizawa

Akihiro Sakamoto

Hideki Matsuda

Hiroaki Kubota

Masahito Tasaka

Norimasa Yamasaki

Ryuji Hamada

Akihiko Yokoyama

The present disclosure provides a compound that exerts an anticancer action based on CHK1 inhibition. The present disclosure was completed by finding that a compound represented by formula (1) or a pharmaceutically acceptable salt thereof exhibits an excellent antitumor action by having a potent inhibitory action against CHK1: wherein R, R, L, V, W, and Q are as defined herein, X, Y, and Z each independently represent CRor a nitrogen atom, wherein X, Y, and Z are not simultaneously CR, and Ris as defined herein.

5-heteroaryl-1H-pyrazol-3-amine derivative

The compound of formula (1a) wherein p is 1 or 2, R-Rare hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.

Optically active azabicyclo ring derivative

The present invention relates to the compound of formula (1a) wherein p is 1 or 2, R-Rare hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin. 

The present invention relates to the compound of formula (I) wherein p is 1 or 2, Ris &#x2014;CFor the like, R, R, R, and Rare hydrogen atom or the like, X is &#x2014;C(&#x2550;O)&#x2014;or the like, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin. 

Optically active crosslinked cyclic secondary amine derivative

The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: wherein X is an oxygen atom and the like; Y is &#x2014;CO&#x2014;, &#x2014;SO&#x2014; and the like; Ris an optionally-substituted Calkyl group, an optionally-substituted Calkylcarbonyl group and the like; Ris an optionally-substituted Calkyl group, an optionally-substituted Calkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R, R, R, and Rare independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof

According to the present invention, there is provided a cooling apparatus for a steel material in which one portion in a longitudinal direction of an elongated steel material () is heated while the steel material is fed in the longitudinal direction in a state where one end portion of the steel material is gripped, and the one end portion is moved in a two-dimensional or three-dimensional direction so as to form the steel material into a predetermined shape including a bent portion and thereafter to cool a heated portion including the bent portion. The cooling apparatus includes a first cooling apparatus () that ejects a first cooling medium to the heated portion, and a second cooling apparatus () that is disposed on a downstream side from the first cooling apparatus when viewed along a feeding direction of the steel material, and that ejects a second cooling medium to the heated portion. A plurality of the second cooling apparatuses are disposed along the feeding direction, and flow rates of the second cooling media can be controlled independently of each other. According to the configuration, it is possible to reduce the insufficient quenching of the steel material.

Cooling apparatus and cooling method for steel material

A bending apparatus has (a) a first manipulator which feeds a hollow metal blank of closed cross section in its lengthwise direction, (b) a second manipulator which supports a first support means disposed at a first position and a metal blank while feeding it, a heating means disposed at a second position downstream of the first position in the blank feed direction for heating all or part of the circumference of the blank, and a cooling means disposed at a third position downstream of the second position for cooling a portion of the heated blank, and (c) a third manipulator which constitutes a second support means disposed at a fourth position downstream of the third position in the feed direction of the blank and which moves two-dimensionally or three-dimensionally while supporting at least one location of the metal blank to bend the metal blank into a desired shape.

Method for manufacturing a bent member

An induction heating coil for stably heating a steel tube which is being fed in its axial direction without rotating, the heating being uniform in the circumferential direction and in a narrow range in the axial direction has at least two 1-turn coils in the form of a first turn coil body and a second turn coil body. The inner peripheral length Ln (the non-effective coil length) where the effective number of coil turns is less than the total number of coil turns when the coil is projected in the axial direction and the inner peripheral length Lof the projected coil bodies (the inner coil length) satisfy Ln/L&#x3c;0.05. First and second coil bodies have insulating portions on their connecting portions, and the insulating portions are present in locations separated by a central angle of 5-45&#xb0; measured from the center of the coil bodies.

Method for manufacturing a worked member using an induction heating coil

A method for manufacturing a bent member, the method includes feeding an elongated steel material in a longitudinal direction with one end portion of the steel material as a head, performing high-frequency induction heating to one portion of the steel material in the longitudinal direction by being supplied high-frequency power to form a high-temperature portion, bending the steel material by applying a bending moment in an arbitrary direction to the high-temperature portion to form a bent portion, and injecting a cooling medium to the bent portion to cool the bent portion. The bending includes forming the bent portion having a ratio R/W which is equal to or lower than a predetermined value, where the ratio R/W is a ratio obtained by dividing a bending radius R [mm] of the bent portion on a centroid line of the steel material by a dimension W [mm] in a bend direction in a cross-section of the steel material orthogonal to the centroid line, slowing down a feeding speed of the steel material less than V, where the Vis the feeding speed of the steel material while forming the bent portion having the ratio R/W which is more than the predetermined value, and reducing the high-frequency power supplied while forming the high-temperature portion less than Q, where the Qis the high-frequency power supplied while forming the bent portion having the ratio R/W which is more than the predetermined value.

Method for manufacturing bent member, and hot-bending apparatus for steel material

A bent product having a three-dimensionally bent portion intermittently or continuously in the lengthwise direction is manufactured by supporting a steel pipe at a first position A while feeding it in the lengthwise direction, locally heating the steel pipe being fed at a second position B, cooling the heated portion of the steel pipe at a third position C, and varying the position of a gripping means, which grips the steel pipe in a region ID downstream of the third position C, in a three-dimensional direction including the feed direction of the steel pipe in a workspace including a space on the upstream side of the third position C in the feed direction of the steel pipe to impart a bending moment to the heated portion of the steel pipe.

Method and apparatus for manufacturing a bent product

A bent product having a three-dimensionally bent portion intermittently or continuously in the lengthwise direction is manufactured by supporting a steel pipe at a first position A while feeding it in the lengthwise direction, locally heating the steel pipe being fed at a second position B, cooling the heated portion of the steel pipe at a third position C, and varying the position of a gripping means, which grips the steel pipe in a region D downstream of the third position C, in a three-dimensional direction including the feed direction of the steel pipe in a workspace including a space on the upstream side of the third position C in the feed direction of the steel pipe to impart a bending moment to the heated portion of the steel pipe.

Growing community of inventors

Osaka, Japan

Naoaki Shimada