Showa Denko K.k.

Showa Denko Kabushiki Kaisha

Naoaki Misu

Eiji Ogata

Shinobu Ito

Yutaka Ohnishi

Tsutomu Nozawa

Yohei Kurata

Keisuke Mano

Yutaka Oonishi

Takami Ooe

Yoshimasa Ishimura

Shinya Matsuhira

Nobutake Mihara

Muneyo Kihara

A method for producing an isocyanatoalkyl (meth)acrylate substantially free of hydrolyzable chloride, comprising adding an amine and/or an imidazole and an epoxy group-containing compound and then purifying by distillation the isocyanatoalkyl (meth)acrylate until a 2-chloropropionic acid isocyanatoalkyl ester of an isocyanatoalkyl acrylate or a 2-methyl-2-chloropropionic acid isocyanatoalkyl ester of an isocyanatoalkyl methacrylate is substantially eliminated.

Method for producing isocyanatoalkyl (meth)acrylate

Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.

Highly purified tocopheryl phosphate, process for producing the same,

High-  purity tocopherol phosphates, process for the preparation

A benzopyran derivative represented by formula (I): ##STR1## wherein R.sub.0 represents an alkyl or alkenyl group having 10 to 20 carbon atoms, R.sub.1 to R.sub.3 each represent a methyl group or a hydrogen atom, and G represents a --CH.sub.2 CH(OH)CH.sub.2 OH or --CH(CH.sub.2 OH).sub.2 group; or a salt thereof, which has a high water-solubility and thus is usable in cosmetics.

Benzopyran derivative, method for producing the same and use thereof

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Fukushima, Japan

Naoaki Misu