The Florida State University Research Foundation, Inc

Emory University

Children's Healthcare of Atlanta, Inc.

University of Delhi

Children's Heatlhcare of Atlanta

Nanting Ni

Binghe Wang

Xiaochuan Yang

Guojing Sun

Shilong Zheng

Chunhao Yang

Chaofeng Dai

Nitin Kumar

Diwan S Rawat

Weixuan Chen

Alexander Draganov

Sunny Manohar

Junfeng Wang

Hanjing Peng

Minyong Li

Chung-Dar Lu

Han-Ting Chou

Yunfeng Cheng

Muxiang Zhou

Lubing Gu

Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

Anthraquinone analogs and methods of making and using thereof

Compounds having Formula I or II, and methods of making and using thereof, are described herein: 

Curcumin analogs and methods of making and using thereof

The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.

Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria

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Goleta, CA, United States of America

Nanting Ni