The Salk Institute for Biological Studies

The University of Sydney

Nanthakumar Subramaniam

Ronald Mark Evans

Michael Downes

Christopher Liddle

Ning Ding

Caroline Flora Samer

The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.

Vitamin D receptor/SMAD genomic circuit gates fibrotic response

This application relates to methods of treating and ameliorating fibrosis, such as fibrosis of the pancreas. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of pancreatic fibrosis.

Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis

Growing community of inventors

Wentworthville, Australia

Nanthakumar Subramaniam