Other

Gongwin Biopharm Co., Ltd

Guangzhou Medical University

Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd.

Baiyunshan Pharmaceutical General Factroy Guangzhou Institute of Respiratory Disease

Nanshan Zhong

Lin Zhang

Mao-Yuan Lin

Wei Wang

Kefang Lai

Shan Zhong

Xiaodong Liu

Ao Shen

Yichu Nie

Zhenyong Gan

Ping Wan

Xiyong Yu

Hongying Mo

Shaoxuan Zhu

Chia-Shun Shih

Hairong Hu

Longjiang Li

Lester J Wu

Wei Liao

Hua Tao

Lixin Zhao

Xianglin Fu

Jin Feng

Qiulian Zhu

Binge Huang

Mao Chen

Jinping Zheng

A polypeptide-coupled small molecule compound and its antiviral applications are provided. The polypeptide-coupled small molecule compound is obtained by linking a polypeptide with a sequence X'nLXGG and a small molecule compound capable of inhibiting activity of papain-like protease (PLpro) of coronavirus through a chemical bond. The polypeptide with the sequence X′nLXGG is a polypeptide with a sequence LXGG at its carboxyl terminal, X and X′ are independently any amino acid, and n is an integer between 1-50. The structure of the small molecule compound capable of inhibiting the activity of PLpro contains an amino group or a hydroxyl group. The polypeptide-coupled small molecule compound can inhibit the PLpro of SARS-CoV-2 in a targeted manner, thereby inhibiting the polyprotein cleavage of coronavirus in the host, and achieving the purpose of inhibiting the replication of coronavirus in the host. It has the advantages of synergistic inhibition, low cytotoxicity and favorable solubility.

Polypeptide-coupled small molecule compound and antiviral application thereof

A pharmaceutical composition exhibiting anti-tumor activity is provided. The pharmaceutical composition comprises para-toluenesulfonamide (PTS) and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for treating squamous-cell carcinoma. The present invention further provides a method for treating a patient suffering from cancer and a method for inhibiting tumor growth.

Pharmaceutical composition exhibiting anti-tumor activity, method for treating patient suffering from cancer and method for inhibiting tumor growth

Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.

S-(carboxymethyl)-cysteine pharmaceutical compound and preparation method and use thereof

The present invention relates to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for treating coughing, and more specifically to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for preventing and relieving coughing and eliminating airway inflammation. Experiments demonstrate that the Fructus schisandrae total polysaccharides can remarkably reduce the coughing times of a guinea pig with increased cough sensitivity induced by cigarette smoke and an acute cough guinea pig induced by citric acid smoke, prolong the latent period of cough, and significantly reduce the airway inflammation of the guinea pig with increased cough susceptibility induced by cigarette smoke, so that the Fructus schisandrae total polysaccharides can be used for preparing drugs for preventing cough, relieving cough and eliminating airway inflammation.

Application of fructus schisandrae total polysaccharides in preparatoin of medicine or nutraceuticals used for treating coughing

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Guangzhou, China

Nanshan Zhong