Codexis, Inc.

Nandhitha Subramanian

Oscar Alvizo

Jovana Nazor

Vesna Mitchell

Ericka Bermudez

David Elgart

Mathew G Miller

Agustina Rodriguez-Granillo

Anna Fryszkowska

Margie Tabuga Borra-Garske

Aksiniya Lyubenova Petkova

Nikki Dellas

Jonathan Vroom

Charlene Ching

David Entwistle

James Nicholas Riggins

Da Duan

Ravi David Garcia

Xiang Yi

Nicholas M Marshall

Deeptak Verma

Grant S Murphy

Donald Scott Baskerville

Auric Anthony Sowell-Kantz

Harvinder Chagger Maniar

Christopher Michael Micklitsch

Lillian Jasmine Miller

Joshua N Kolev

Sandy M Gomes

Mikayla Jianghongxia Krawczyk

Nikki D Kruse

Jesse B Slaton

Dewan Andrews

The present application provides engineered glucose dehydrogenase polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds

The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.

Engineered DNA polymerase variants

The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Engineered pantothenate kinase variant enzymes

The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.

The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.

Engineered galactose oxidase variant enzymes

The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing peroxidase enzymes are also provided. The present invention further provides compositions comprising the peroxidase enzymes and methods of using the engineered peroxidase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.

Peroxidase activity towards 10-acetyl-3,7-dihydroxyphenoxazine

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Cambridge, United Kingdom

Nandhitha Subramanian