Regeneron Pharmaceuticals, Inc.

Lifecodes Corporation

Other

University of California

Nancy Y Ip

George D Yancopoulos

David M Valenzuela

William C Smith

Mark E Furth

Richard M Harland

Howard J Baum

Henryk D Cudny

Anne Knecht

Teresa Lamb

Neil E Stahl

Zvi Gerald Loewy

Nikos Panayotatos

Friedrich Lottspeich

Stephen P Squinto

Vivien Wong

Hans Thoenen

Ronald M Lindsay

Piotr J Masiakowski

Eric M Shooter

Ulrich Suter

Peter S DiStefano

Yoshihiro Arakawa

Kurt Stockli-Rippstein

Michael Sendtner

Georg W Kreutzberg

Rudolf Georg Gotz

Dan B Lindholm

Susan L Leary

Ingrid L Van De Stadt

Patrick Desmond Carroll

Henryk Cudny

DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby

Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described.

Dorsal tissue affecting factor and compositions

Human dorsal tissue affecting factor (noggin) and nucleic acids encoding

An assay system useful for detecting denervated or degenerating muscle by measuring the amount of soluble ciliary neurotrophic factor receptor in body fluids is described.

Assay system for degenerative muscle disease

A method for obtaining polynucleotide sequences which are useful for detecting Variable Tandem Repeat polymorphism at multiple genetic loci and other genetic analyses under high stringency conditions (hence, with high specificity) is herein disclosed. Also disclosed are polynucleotide sequences and other compositions useful for DNA polymorphism and other genetic analyses.

Compositions and methods useful for genetic analysis

Polynucleotide sequences and other compositions useful for DNA polymorphism and other genetic analyses are disclosed herein. Also disclosed is a method for obtaining Variable Tandem Repeat polymorphism at a single genetic locus as well as other genetic analyses.

Compositions and protocols applicable to genetic analysis

The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occurring cellular factor and a portion of at least one other molecule such that the resulting chimeric molecule has neurotrophic activity. It is based, in part, on the discovery that chimeric molecules comprising portions of both NGF and BDNF are likely to possess neurotrotrophic activity, and in some cases exhibit a spectrum of activity larger than that of either parent molecule. It is further based on the discovery that chimeric molecules comprising neurotrophic factor sequences as well as additional peptide sequences may retain neurotrophic activity, and in some cases may exhibit a more potent activity than the parent factor. The chimeric neurotrophic factor molecules of the invention provide a number of advantages relative to naturally occurring neurotrophic factors. Chimeric neurotrophic factors may be used to provide, for example, the activity of two neurotrophic factors in a single molecule, or may serve as superagonists of an endogenous neurotrophic factor, thereby enabling an increased biological response at lower doses. Nucleic acids and plasmids encoding the chimeras are disclosed.

Multitrophic and multifunctional chimeric neurotrophic factors, and

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Stamford, CT, United States of America

Nancy Y Ip