Merck + Co., Inc.

Nancy N Tsou

Nobuyoshi Yasuda

Chunhua Yang

Scott D Feighner

Jack L Smith

Gino M Salituro

Richard G Ball

James A Mc Cauley

Novel crystalline carbapenem intermediate compounds of formula I: ##STR1## wherein: R.sub.1 represents CH.sub.3 or H and an efficient process for synthesis thereof are described.

Crystalline imidazole complexes as carbapenem intermediates and synthesis

Unguinol is a well-known metabolite of the fungi Aspergillus unguis and Aspergillus nidulans. Unguinol has been found to be an active growth permittant and promotant in animals, in particular, monogastric animals such as chickens. In addition, the fermentation broth also produced the additional known unguinol derivatives of folipastatin and 2-chloro unguinol as well as the novel 4-methyl derivative. All of these compounds are active animal growth permittants. Compositions containing such unguinol derivatives for use as growth permittants and promotants are also disclosed.

Unguinol and analogs are animal growth permittants

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Westfield, NJ, United States of America

Nancy N Tsou