USA as Represented by Secretary of the Navy

Nancy Millenbaugh

Dickson Kiprono Kirui

Jeremy Wesley Gleaton

Jonathan Baskin

William R Elliot

Mauris DeSilva

Jeevalatha Vivekananda

Sabrina Snyder

Crystal Rock

Methods of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antifungal peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7 are described. Antifungal pharmaceutical compositions and dosage forms, including field-deployable dosage forms, comprising one or more of these antifungal peptides are also described.

Methods of treating fungal infections

This application describes a method of using gold nanoparticle (GNP)-targeted pulsed laser technology to enhance antibiotic efficacy against multidrug resistant biofilms. The application also teaches a method for treating topic wound infection using GNP-targeted laser therapy combined with antibiotics treatments.

Method of treating multi-drug resistance biofilm using targeted laser and antibiotics

The invention relates to methods of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antifungal peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7. Antifungal pharmaceutical compositions and dosage forms, including field-deployable dosage forms, comprising one or more of these antifungal peptides are also contemplated herein.

The present invention is related to novel functional antibody coated nanoparticles, and the preparation method thereof. The functional antibody coated nanoparticles according to the present invention can be used as photothermal agents to effectively inhibit the growth of microbes including drug-resistant strains and biolfilm with laser irradiation.

Method of using laser-induced optoacoustics for the treatment of drug-resistant microbial infections

Antifungal pharmaceutical compositions, dosage forms, and methods of use thereof are disclosed.

The present invention is related to novel functional antibody coated nanoparticles, and the preparation method thereof. The functional antibody coated nanoparticles according to the present invention can be used as photothermal agents to effectively inhibit the growth of microbes including drug-resistant strains and biofilm with laser irradiation.

Aptamers and methods of use thereof are presented for the treatment or diagnosis ofinfection. The aptamers binds to and capable of neutralization ofalpha-toxin.

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San Antonio, TX, United States of America

Nancy Millenbaugh