Becton Dickinson and Company Limited

Nancy L Shields

Donald D Solomon

Can B Hu

Fidelis C Onwumere

A thermoplastic polyurethane having prolonged biostability has tertiary amino groups in the polymer chain. Protonation of the amino groups with an aqueous acid causes the polymer to absorb up to 1,700% by weight of water and swell. The protonated amino groups form a complex with an antithrombogenic agent to give an antithrombogenic polyurethane. The invention includes a shaped article of the polyurethane.

Biostable polyurethane

A method for heparinizing a substrate includes applying a coating of ammonium salt to a substrate by steeping the substrate in a solution of the salt at an alkaline pH and contacting the coated substrate with a solution of a salt of heparin.

Growing community of inventors

Dayton, OH, United States of America

Nancy L Shields