Atrix Laboratories, Inc.

Nancy L Krinick

Richard L Dunn

Arthur J Tipton

Gerald L Yewey

Michael L Radomsky

Gerbrand Brouwer

Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

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Fort Collins, CO, United States of America

Nancy L Krinick