Wisconsin Alumni Research Foundation

Other

Nancy Keller

Jin Woo Bok

Jon Duvick

Joyce R Maddox

Saori Amaike Campen

Philipp Wiemann

Saori Amaike

A method of promoting fungal spore germination. The method includes the step of contacting a fungal spore with a germination-promoting concentration of an exogenous imizoquin.

Method to induce spore germination in fungi

The present invention discloses methods and systems for producing fungal secondary metabolites. The invention also discloses genetically modified organisms and kits including such organisms for producing fungal secondary metabolites.

Methods and systems for producing fungal secondary metabolites

The invention provides a general and facile method to obtain secondary metabolites from fungal sources. The invention is based on the discovery that the fungal gene veA and protein encoded thereby regulates the activity of multiple secondary metabolite gene clusters in fungi. Over expression of the gene veA provides increased production of secondary metabolites in engineered cells. In particular, such a method of increasing secondary metabolite production allows the production of improved yields of valuable secondary metabolite products.

Over-production of secondary metabolites by over-expression of the VEA gene

The invention provides polypeptides and nucleic acids which identify and encode LaeA, a regulator of fungal secondary metabolite production which exhibits global control over secondary metabolite biosynthetic gene clusters. The invention further provides expression vectors, host cells, methods of increasing the production of secondary metabolites in an organism naturally producing a secondary metabolite or engineered to produce a secondary metabolite, and methods of identifying novel secondary metabolite biosynthesis gene clusters.

Global regulator of secondary metabolite biosynthesis and methods of use

The invention provides isolated maize lipoxygenase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering lipoxygenase concentration and/or composition of plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants.

Growing community of inventors

Madison, WI, United States of America

Nancy Keller