Shire LLC

New River Pharmaceuticals Inc.

Nancy Johnston Boerth

Thomas Piccariello

James Scott Moncrief

Travis C Mickle

Barney Bishop

Lawrence Peter Olon

Alex Saunders Goldstein

The invention provides a 'street-safe' version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.

Carbohydrate conjugates to prevent abuse of controlled substances

The present invention relates to compositions comprising thyroxine (T4) and triiodothyronine (T3). More specifically, the invention relates to thyroxine (T4) and triiodothyronine (T3) compositions that include a peptide carrier and thyroxine (T4) and triiodothyronine (T3) covalently attached to at least one of the N-terminus, the C-terminus, a side chain of the peptide carrier, and/or interspersed within the peptide chain; methods for protecting and administering thyroxine (T4) and triiodothyronine (T3); and methods for treating thyroid disorders.

Iodothyronine compositions

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Blacksburg, VA, United States of America

Nancy Johnston Boerth