Coopervision International Limited

The University of Melbourne

Coopervision International Holding Company, LP

Nancy J Keir

Victoria Rogers

Erwin C Si

Inna Maltseva

Yuwen Liu

Subam Basuthkar Sundar Rao

Paul Richardson

Sourav Saha

Tim Warren

Xinfeng Shi

Matthew S Linn

Lu Jiang

James Mun

David Charles Jackson

Arthur Bradley

Andrew Luk

Laura Elizabeth Downie

Sarah Tao

Yuan Sun

Charles B Derringer

Szeshen Chuah

Algis Jonas Vingrys

Yuan Ji

Hyo Jeang Lee

A WS12-releasing contact lens is described as well as method of manufacturing the same. The WS12-releasing contact lens comprises a polymeric lens body and WS12 releasably adhered to the polymeric lens body, and releases from 0.05 μg to 0.5 μg WS12 after 1 hour in a release media or when worn by a human subject. The WS12-releasing contact lens can be comfortably worn by a symptomatic contact lens wearer and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer.

WS12-releasing contact lens

An oleic acid-releasing contact lens is described as well as method of manufacturing the same. The oleic acid-releasing contact lens contains oleic acid releasably adhered to the polymeric lens body, and releases from 2 μg to 25 μg oleic acid after 1 hour in a release media. The oleic acid-releasing contact lens can be comfortably worn by a symptomatic contact lens wearer, and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events in a symptomatic contact lens wearer.

Oleic acid-releasing contact lens

A WS12-releasing contact lens is described as well as method of manufacturing the same. The WS12-releasing contact lens comprises a polymeric lens body and WS12 releasably adhered to the polymeric lens body. The amount of WS12 releasably adhered to the polymeric lens body provides a basal tear concentration in lens wearers of 2 μg/ml to 8 μg/ml WS12 after 30 minutes of lens wear. The WS12-releasing contact lens can be used to increase contact lens comfort, reduce eye fatigue, reduce sensations of ocular dryness and impart a pleasant, cooling sensation in the lens wearer without causing stinging or burning upon insertion.

A contact lens having an amount of at least one cooling agent and at least one TRPV1 inhibitor releasably adhered is described as well as method of manufacturing the same. The contact lens can be comfortably worn by contact lens wearers and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer and further can reduce or avoid any stinging/burning sensation when the contact lens is first used or a short time thereafter.

Contact lens

Methods and devices to identify contact lens wearers predisposed to contact lens discomfort are described. The methods and devices involve obtaining a tear film sample from a person and determining an amount of interleukin-17A present in the tear film sample.

Identification of contact lens wearers predisposed to contact lens discomfort

A contact lens having antioxidant properties is described as well as methods of manufacturing the same. The contact lens can be present in a sealed contact lens package. The seal contact lens package can include at least a) a plastic base member having a cavity; b) a contact lens packaging solution in the cavity; c) a sterile, unworn contact lens immersed in the contact lens packaging solution in the cavity; and d) a cover that forms a liquid-tight seal with the plastic base member. As an example, the unworn contact lens is a silicone hydrogel contact lens having present therein vitamin E. The vitamin E is non-releasable from the unworn contact lens and the contact lens packaging solution has less than 1 ppm of vitamin E present. The vitamin E is trapped, embedded, absorbed, or non-covalently attached in the unworn contact lens.

Antioxidant contact lens

A contact lens comprising one or more microchannels for transport of liquid through the lens is provided. The contact lens can be made by contacting a curable composition with a microfiber that is insoluble in the curable composition; curing the curable composition to provide a polymeric lens body with the microfiber embedded therein; and contacting the polymeric lens body with a solvent to dissolve the microfiber.

Contact lenses with microchannels

A contact lens having dimples on a posterior surface is described as well as cast molds and injection molding inserts for manufacturing the same. The contact lens includes a posterior surface having an optic zone, a peripheral zone, and a circumferential edge, where dimples are located in the peripheral zone, and can include at least 1000 dimples.

Dimpled contact lens

A wettable silicone hydrogel contact lens having a low ionoflux and low evaporation is manufactured by curing a silicone hydrogel polymerizable composition in a contact lens mold comprising front and back lens-forming surfaces, where one of the lens-forming surfaces has a higher polarity than the other lens-forming surface.

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Pleasanton, CA, United States of America

Nancy J Keir