Abbott Gmbh & Co Kg

Nancy J Bump

Lee Daniel Arnold

Richard W Dixon

Hans Wolfgang Hoeffken

Karen Nazaretian Allen

Cornelia Bellamacina

The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The invention also relates to the use of the three dimensional structure of the Tie-2 catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Tie-2 activity, for example, compounds which inhibit the binding of a native substrate to the Tie-2 catalytic domain.

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Lowell, MA, United States of America

Nancy J Bump