Genzyme Corporation

Integrated Genetics, Inc.

Nancy Hsiung

Anton K Beck

Vermuri B Reddy

Edward G Bernstine

Edward G Berstine

Vemuri B Reddy

William R Dackowski

Jeffrey F Lemontt

Edward S Cole

Renee A Fitts

Cha-Mer Wei

Dean H Hamer

David Tai-Yui Lau

Richard D Purcell, Jr

Richard Douglas

Vermuni B Reddy

Edward George Bemstine

Biologically active heteropolymeric protein composed of a plurality of subunits, both subunits being synthesized in a single cell having an expression vector comprising heterologous DNA encoding the subunits. Preferably the protein is similar to the human or ungulate fertility hormones, LH and FSH.

Cells, vectors and methods for producing biologically active TSH

Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.

Nucleic acids encoding and recombinant production of the .beta. subunit

Recombinant heterodimeric human fertility hormones, and methods, cells,

The correct sequence is disclosed for the beta subunit of human follicle stimulating hormone which, when present in a recombinant heterodimeric human fertility hormone allows the production of biologically active hormone. DNA coding for such beta subunit of human FSH may thus be prepared as well as expression vectors containing such DNA and cells transfected therewith.

DNA encoding the beta subunit of human follide stimulating hormone and

A replicable expression vector capable, in a transformed host mammallian cell, of expressing a DNA sequence encoding active human TPA which, when expressed in the host cell, yields active TPA which lacks one or more of the TPA-bound N-linked carbohydrate moieties of naturally occurring human TPA.

Human uterine tissue plasminogen activator produced by recombinant DNA

Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.

Follicle stimulating hormone

Biologically active heteropolymeric protein composed of a plurality of subunits, each subunit being synthesized by a cell having an expression vector heterologous DNA encoding the subunit.

Heteropolymeric protein

Recombinant DNA vector including (1) a promoter for a eukaryotic metalliothionein gene ligated to a gene sequence encoding hepatitis B surface antigen, and (2) at least the 69% transforming region of the bovine papilloma genome, expression of the hepatitis B surface antigen encoding gene sequence being under the control of the metallothionein promoter.

Growing community of inventors

Wellesley, MA, United States of America

Nancy Hsiung