Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd.

Nan Yu

Jingyi Wang

Lichun Wang

Hong Zeng

Mingliang Zhao

Wei Zhong

Donghai Su

Hua Deng

Hongmei Song

Jiaqiang Cai

Qiang Tian

Yongyong Wu

Haitao Huang

Yan Qing

Xin Zhou

Yuting Tan

Hong Ye

Gang Liu

Wenjia Li

Donghong Li

Shaohua Li

Long Yang

Xunwei Wu

Lei Wu

The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with &#x3ba;-opioid receptor. The polyamide compound of the invention has excellent &#x3ba;-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a &#x3ba;-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.

Polyamide compound and use thereof

The present invention relates to a novel compound of 4'-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4&#x2032;-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.

Compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof

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Wenjiang, China

Nan Yu