Shaanxi University of Science and Technology

Shaanxi Panlong Pharmaceutical Co., Ltd.

Tianjin Medical University

Nan Qin

Chengyuan Liang

Han Li

Lei Tian

Juan Xia

Yuzhi Liu

Zhenfeng Shi

Xingke Ju

Jingyi Li

Liang Xin

Xuechuan Wang

Xiaolin Xie

Dezhu Zhang

Taotao Qiang

Zhao Ma

Kangxiong Wu

Xuhua Zhou

Shaojun Zhang

Catherine J Lee

Maggie Lewis

Shaomeng Pei

Qingbo Zhao

Min Li

Bin Tian

Qianqian Zhao

Gennian Mao

Juan Li

Nan Hui

Ying Chen

Mi Wu

Hongquan Duan

Wenyan Niu

Meina Jin

Lihuan Shi

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Protacs targeting coronavirus 3CL protease and preparation method and application thereof

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof

A compound of chemical formula I: or chemical formula II: or a pharmaceutical acceptable salt thereof is disclosed. R, R, R, and Rare independently H, halogen, nitro, hydroxyl, cyano, benzyloxy, C-Cstraight or branched alkyl, C1-C8 straight or branched haloalkyl, C-Cstraight or branched alkoxy.

Alantolactone/isoalantolactone spiro aryl isoxazoline compounds

A compound of chemical formula I: or formula II: or a pharmaceutical acceptable salt thereof is disclosed. Ris OH or OAc; X is C or N; and Ris H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO, or halogen, provided that when X is N, Ris nil.

1-O-acetylbritannilatone spiro aryl isoxazoline compounds

A compound having the following formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.

Hydroxytyrosol shikimic acid ester for treating cardiovascular deceases and a method of preparing the same

Flavone derivatives, preparative method of the derivatives and use thereof as medicaments for treating diabetes. The structure of the derivatives is presented by formula 1: In the structure, Rand R, which are identical or not, represent hydrogen atom, halogen, cyano, hydroxyl, trifluoromethyl, thio-methyl, benzyloxy. C1-C8 linear chain or branch chain alkyl, C1-C8 linear chain or branch chain alkoxy. The pharmacological test indicates that the flavone derivatives can significantly increase the glucose consumption of Hep-G2 cell with insulin resistance activity, promote translocation of glucose transporter 4 of skeletal muscle cells (L6GLUT4myc) at different level, and significantly increase glucose intake and utilization by cells. The test proves the fact for the first time that the flavone derivatives can significantly promote translocation of glucose transporter 4 of skeletal muscle cells, and one of the mechanisms for treating diabetes is activating the cell AMPK phosphorylation and phosphorylating the downstream ACC.

Flavone derivatives and their preparative method and medical use

Growing community of inventors

Tianjin, China

Nan Qin