University of Pretoria

Other

University of Kwazulu-Natal

Namrita Lall

Danielle Twilley

Marco Nuno De Canha

Indres Moodley

Ahmed Hussein

Jacobus Johannes Marion Meyer

Elizabeth Mogapi

Isa Anina Lambrechts

Richa Sharma

Navneet Kishore

Indhrasen Moodley

Francina Susanna Botha

Ahmed Abdel-Fattah Hussein

Cynthia Joan Henley-Smith

The invention relates to an extract from, or a bioactive mixture consisting essentially of oleanolic acid and ursolic acid isolated from, for use in preventing and/or treating skin cancer, more specifically melanoma, and for reducing skin damage resulting from UV radiation. The invention also relates to uses and methods of treating skin cancer and reducing skin damage resulting from UV radiation using the extracts and/or bioactive mixture described. The invention further relates to an anticancer composition comprising the extracts and/or bioactive mixture, that inhibits angiogenesis and/or proliferation of cells associated with melanoma, as well as a sunscreen composition comprising the extracts and/or bioactive mixture.

Anticancer activity ofcompositions

The invention provides a pharmaceutical composition suitable for topical application. The pharmaceutical composition comprises an extract of Plectranthus aliciae and a pharmaceutically acceptable carrier. The invention extends to provide a pharmaceutical composition for the treatment of acne, a pharmaceutical gel composition, a substance or composition comprising an extract of Plectranthus aliciae, a use of a Plectranthus aliciae extract, and various methods of preventing or treating acne.

Anti-acne pharmaceutical compositions

This invention relates to the isolation, and use of a plant extract in the treatment of skin hyper-pigmentation. More particularly, this invention relates to the isolation of a tyrosinase inhibitor in an extract of plant matehal from the() plant, the extract including 5,7-dihidroxyflavone[(2S)-pinocembrin]; 2',6&#x2032;-dihydroxy-4&#x2032;-methoxydihydrochalcone; 2&#x2032;,4&#x2032;,6&#x2032;-trihydroxyhydrochalcone; 3,5,7-trihydroxyflavone and 4&#x2032;,5&#x2032;7-thhydroxyisoflavone.

Extract ofand use thereof

The present invention relates to extracts fromfor use in the prevention of and treatment of skin cancer. The invention also provides for pharmaceutical compositions containing the extract and to the use of medicaments containing the extract.

[object Object]

Naphthoquinone derivatives of Formula (1): wherein R, represents an OH group, methyl ether, ethyl ether or a similar ether, R1 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative: R2 and R3 each independently represent hydrogen or a group selected from: (A), (B), or (C) wherein R5 represents an PH group, methyl ether, ethyl ether or a similar ether and R6 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative: R4 represents hydrogen or a group selected from: (D), (E) or (F) wherein R7 represents an OH group, methyl ether, ethyl ether or a similar ether and R8 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative: or pharmaceutically acceptable salts thereof, are useful for the treatment and/or control of a in a patient caused by

Naphthoquinone derivatives and their use in the treatment and control of tuberculosis

Growing community of inventors

Pretoria, South Africa

Namrita Lall