Myeloid Therapeutics, Inc.

Children's Medical Center Corporation

Ganna Bio, Inc.

Namita Bisaria

Daniel Getts

Yuxiao Wang

Inna Shcherbakova

Socheata Ly

Carolyn Ruth Bertozzi

Brian Goodman

Richard D Cummings

Ciaran Lawlor

Ryan A Flynn

Mohui Wei

Methods and composition for modulating a target genome and stable integration of a transgene of interest into the genome of a cell are disclosed.

Methods and compositions for genomic integration

The present disclosure relates to glycan-modified nucleic acids, including short interfering RNA molecules. The glycan-modified nucleic acids include an oligosaccharide moiety that is bond to the nucleic acid and that contains a multiple antennary complex type N-glycan. The disclosure also relates to pharmaceutical compositions containing such glycan-modified nucleic acids, and methods for making and using such glycan-modified nucleic acids.

Glycan modified short interfering RNA

Growing community of inventors

Somerville, MA, United States of America

Namita Bisaria