Washington University

Nalinikanth Kotagiri

Samuel I Achilefu

The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT).

Imaging and treatment of pathophysiologic conditions by Cerenkov radiation

The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention encompasses a method for administering Cerenkov radiation-induced therapy (CRIT) to a target tissue in a subject. The method comprises administering to the subject an effective amount of a composition B comprising at least one radiation-sensitive molecule and administering to the subject an amount of a Cerenkov radiation (CR)-emitting radionuclide effective to activate the radiation-sensitive molecule, thereby administering CRIT to the target tissue in the subject.

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St. Louis, MO, United States of America

Nalinikanth Kotagiri