Ipca Laboratories Limited

Nalinakshya Balaram Panda

Ashok Kumar

Satish Rajanikant Soudagar

Manmohan Nimbalkar

Abhay Atmaram Upare

Rajesh Kumar Keshava Prasad Singh

Ashvini Kumar Nand Kishore Saxena

Sanjay Tukaram Gunjal

Rajeshkumar Singh

Dilip Uttam Jadhav

Mathur Arpana

New compounds useful as synthetic intermediates to synthesize perindopril, a new process for synthesizing perindopril, and new salts of perindopril.

Process for manufacture of pure (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl]amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid and its tert. butyl amine salt

Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of Losartan potassium by use of alkali metal salt such as Potassium carbonate is disclosed. A process for preparation of the polymorphic Form I of Losartan potassium is also disclosed herein.

Process for the synthesis of Losartan potassium

A process for the synthesis of Losartan Potassium by reacting Trityl Losartan in a primary alcohol with potassium tertiary alkoxide.

Losartan potassium synthesis

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Thane, India

Nalinakshya Balaram Panda