Columbia University

Nalin Tejavibulya

Samuel K Sia

Matthieu Jean Michel Rueegg

At least one microneedle comprises a hydrogel material that includes a substance that fluoresces when the substance interacts with an analyte. A magnitude of the fluorescence varies as a function of the concentration of the analyte. During use, the hydrogel material is illuminated with illumination light in a first wavelength range while the hydrogel material interfaces with the dermal interstitial fluid layer of a subject, and a photosensor generates an output that corresponds to an amount of light received in a second wavelength range.

Devices and systems for optically determining a concentration of an analyte in a living subject using hydrogel-based, fluorescent microneedles and methods of manufacture thereof

Devices systems and methods for fluid extraction and delivery to human or animal hosts are described. In embodiments, microneedles are employed to provide low infection risk and painless access to and administration of fluids. The disclosed embodiments address, among others, issues of cost, portability, ease of use in remote settings including use by untrained personnel, and others.

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New York, NY, United States of America

Nalin Tejavibulya