Pfizer Corporation

Nakao Kojima

Hiroyuki Nishida

Nobuji Yoshikawa

Yasuhiro Kojima

Katsuomi Ichikawa

Yuji Yamauchi

Hideo Hirai

Taisuke Inagaki

Kunio Satake

Masaya Ikunaka

Liang H Huang

Walter P Cullen

Mark A Guadliana

Satoshi Nishiyama

Gloria J Kostek

Bernard Frank Bishop

Keiji Kaneda

Tatsuo Sakakibara

Koenraad A Dekker

Toshiyuki Saito

5-substituted picolinic acid compounds production by Marasmiellus sp

This invention provides terpenoid lactone compounds, and processes for producing the terpenoid lactone compounds, which comprise cultivating FERM BP-5778 and then isolating the terpenoid lactone compounds from the fermentation broth. The present invention also provides a pharmaceutical composition comprising the terpenoid lactone compound, which is useful in the treatment of IL-1 and TNF mediated diseases or the like.

Oidiodendron strain for the production of terpenoid lactone compounds

This invention provides terpenoid lactone compounds, and processes for producing the terpenoid lactone compounds, which comprise cultivating,FERM BP-5778 and then isolating the terpenoid lactone compounds from the fermentation broth. The present invention also provides a pharmaceutical composition comprising the terpenoid lactone compound, which is useful in the treatment of IL-1 and TNF mediated diseases or the like.

Terpenoid lactone compounds and their production process

This invention provides terpenoid lactone compounds, and processes for producing the terpenoid lactone compounds, which comprise cultivating,FERM BP-5778 and then isolating the terpenoid lactone compounds from the fermentation broth. The present invention also provides a pharmaceutical composition comprising the teipenoid lactone compound, which is useful in the treatment of IL-1 and TNF mediated diseases or the like.

The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof:

5-substituted picolinic acid compounds and their method of use

This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocylic lactone compound from the fermentation broth. The compounds produced by this process include a compound of the following formula:

Macrocyclic lactone compounds and their production process

The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 are independently H, C.sub.2 -C.sub.6 acyl or halo-substituted benzoyl; and R.sup.3 is --C(O)O--C.sub.1 -C.sub.6 alkyl, C(O)OH, CN, CONH.sub.2, CONHCH.sub.3, CON(CH.sub.3).sub.2, 1-methyltetrazole or 2-methyltetrazole, with the proviso that when R.sub.2 is acetyl and R.sup.3 is methoxycarbonyl, R.sup.1 is not H; and that when R.sup.3 is CN, CONH.sub.2, CONHCH.sub.3, CON(CH.sub.3).sub.2, 1-methyltetrazole or 2-methyltetrazole, R.sup.1 and R.sup.2 are H. The present invention also relates to a pharmaceutical composition comprising compound of the present invention, which is useful in the treatment of IL-1 and TNF mediated diseases or the like. The present invention further relates to a process for producing the compounds of the formula (I).

5-Substituted picolinic acid compounds and their production process

Quinolone compounds for the treatment of disorders caused by

This invention provides processes for producing novel cyclic peptide compounds, which comprise cultivating Ctenomyces serratus FERM BP-5731 and then isolating the cyclic peptide compounds from the fermentation broth. The compounds produced by these processes include a cyclic peptide compound of the following formula (I): ##STR1## The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of severe pain, detoxication of narcotics dependency or acute narcotics intoxication or the like.

Cyclic peptide compounds and their production process

Antiparasitic pyrrolobenzoxazine compounds

Rapamycin producer

Streptomyces braegensis strain and its cultivation in a process for

Growing community of inventors

Chita-gun, Japan

Nakao Kojima