Other

Kuraray Co., Ltd.

Yamanouchi Pharmaceutical Company Ltd.

Kayaku Antibiotics Research Co., Ltd.

Kayaku Antibiotic Research Co., Ltd.

Asai Germanium Research Institute

Mitsubishi Chemical Industries Limited

The Green Cross Corporation

Kirin Brewery Company, Limited

Kabushiki Kaisha Saikin Kagaku Kenkyujo

Kirin-seagram Limited

Kabushiki Kaisha Kayaku Kosei Bushitsu Kenkyujo

Nakao Ishida

Hiroshi Maeda

Fujio Suzuki

Ryunosuke Kanamaru

Minoru Ueda

Toshihiko Yoshitake

Hiroshi Satoh

Kouhei Miyao

Ituro Mizutani

Fumio Kitame

Mikio Kikuchi

Toshikatsu Fujii

Akira Kamata

Keiji Tamura

Tsutomu Okada

Hiroshi Saitoh

Yoshiji Matsuda

Hiroaki Motoki

Kiyoto Edo

Yoshio Koide

Kuniko Utsushikawa

Tomoaki Kohama

Takuya Saito

Substantially pure neocarzinostatin anticancer agents have the formula (A):

Neocarzinostatin derivatives and method of producing the same

Neocarzinostatin derivatives and a process for manufacturing the same

Novel neocarzinostatin anticancer agents have the formula:

Neocarzinostatin complexes, a method for producing the same, and an

Therapeutic induction of interferon production in living animal cells is effected by subjecting such cells to the species-specific interferon inducing effect of an organogermanium compound having the formula:

Organogermanium induction of interferon production

The specification describes novel antibiotic NCS-C and its free acid salts. Their antimicrobial effects are at least comparative with neocarzinostatin, and, against some microorganisms, superior. The novel antibiotic NCS-C or its free acid salt is prepared either by culturing an NCS-C yielding microorganism belonging to the Streptomyces family in a culture medium, separating the culture medium into bacterial bodies and culture filtrate, and extracting the culture filtrate with a water-immiscible polar organic solvent under acidic conditions, or by decomposing neocarzinostatin under acidic conditions and extracting resultant free acid salt with a polar organic solvent.

Novel antibiotic NCS-C and preparation method of the same

The present invention provides a method for the preparation of a specific immune serum by immunizing IAP in animals other than humans and absorbing the thus obtained serum with normal human serum.

Immune serum for diagnosis of cancer and preparation thereof

KS-2-B was obtained as purified material from the culture of Daedalea dickinsii KSDD 6 (FERM-P No. 3993), Lentinus edodes KSLE 7 (FERM-P No. 3994) or Lentinus edodes KSLE 28 (FERM-P No. 4196). This substance, KS-2-B, is an effective interferon inducing substance.

KS-2-B

Neocarzinostatin derivatives having the formula; ##STR1## wherein N represents a neocarzinostatin residue, and R.sub.1 +R.sub.2 represents a residue of polystyrene-maleic acid copolymer having a molecular weight of 2,500 to 80,000. These neocarzinostatin derivatives are prepared by reacting neocarzinostatin with a polystyrene-maleic acid copolymer containing at least one maleic anhydride residue per molecule. The neocarzinostatin derivatives exhibit anticarcinogenic activity.

Neocarzinostatin derivatives and a process for producing the same

KS-substance was obtained as raw material from the cultured mycelium of Daedalea dickinsii KSDD 6 (FERM-P No. 3993), Lentinus edodes KSLE 7 (FERM-P No. 3994) or Lentinus edodes KSLE 28 (FERM-P No. 4196), and by refining this substance a novel substance KS-2-A was obtained. This substance KS-2-A and also the KS-substance as the raw material both enhance the host defense function of the living body.

KS-2-A

7-Hydroxycholesterol and 7-ketocholesterol can be used as a medicament having a pharmacodynamic action on the bio-protective mechanisms, and thus they are useful as an immunoregulatory agent or antiphlogistic agent.

Cholesterol derivative-based medicaments acting on bio-protective

A prophylactic and therapeutic composition effective in the treatment of coccidiomycosis and including a new antibiotic known as TS-0822.

Antibiotic TS-0822

3-(5,7-Dimethyl-2-hydroxy-4-oxo-6,8-decadienyl)-glutarimide is prepared by cultivating Streptomyces pluricolorescens var. yamashitaensis (S-885) ATCC No. 21956 in an aqueous nutrient broth containing a carbohydrate and a source of organic nitrogen until said broth achieves substantial antiviral activity, and recovering said antibiotic from said culture broth. This antibiotic is effective against the viruses of polio and A-type influenza.

3-(5,7-Dimethyl-2-hydroxy-4-oxo-6,8-decadienyl)-glutarimide as an

An inducer of interferon for the viral infection composed mainly of double stranded RNA is extracted and isolated from spore or mycelium of natural or cultivated basidiomycetes such as Cortinellus Shiitake.

Composition containing double stranded RNA from basidiomycetes and

Growing community of inventors

Sendai, Japan

Nakao Ishida