Astellas Pharma Gmbh

Other

National Institute of Advanced Industrial Science and Technology

Yamanouchi Pharmaceutical Company Ltd.

Nagase Co., Ltd.

Nakako Arao

Koji Nagai

Kazuma Kamigiri

Haruo Seto

Nobuaki Shindo

Kazuo Shin-Ya

Masamichi Mori

Kinya Souda

Kouichi Tanaka

Ryuichiro Kurane

Masato Watanabe

Kunio Kosaka

Ken-ichi Suzuki

Toshitsugu Miyazaki

Akira Nakagawa

Yasuhiro Kawano

Kenichi Suzumura

Masakazu Yamaoka

Senji Takahashi

Yuuko Osanai

There are provided a novel microorganismsp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl &#x3b1;-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and &#x3b1;-L-rhamnopyranoside produced thereby. This novel microorganism is a gram-negative bacillus isolated from soil and shows motility owing to polar flagellum. The &#x3b1;-L-rhamnopyranoside, which is produced by culturing the microorganism under aerobic conditions at a culture temperature of 10 to 37&#xb0; C. and at a medium pH of about 5 to 9 usually for about 1 to 7 days, is useful as a highly safe and stable whitening agent.

Microorganism, its product and utilization thereof

This invention relates to a novel compound which has a cytotoxic activity and TGF-&#x3b2; like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.

Depsipeptide compound

A microorganism belonging to the genusis cultured and thiopeptide compounds QN3323 and thiocillin I/II compounds are collected from the culture medium. The compounds are useful as drugs to treat infections caused by multidrug-resistant bacteria.

Thiopeptide compounds

This invention relates to a novel compound which has a cytotoxic activity and TGF-&bgr; like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.

Growing community of inventors

Tokyo, Japan

Nakako Arao