Illumina Corporation

Illumina Cambridge Limited

Naiqian Zhan

John M Beierle

Peyton Shieh

Wei Wei

David Louis Heiner

Alexandre Richez

Sean M Ramirez

James M Tsay

Sang Ryul Park

Kevan Samiee

Ludovic Vincent

Anmiv Prabhu

Tyler Jamison Dill

Scott William Bailey

Robert Yang

Edwin Li

Yuxiang Huang

Valerie Uzzell

Kristina Munoz

Leonid Malevanchik

Samantha Schmitt

Sunmin Ahn

Randall Smith

Michael S Graige

Alexander Fuhrmann

An array includes a support including a plurality of discrete wells, a gel material positioned in each of the plurality of discrete wells, and a quality control tracer grafted to the gel material in each of the plurality of discrete wells. The quality control tracer comprises (a) a cleavable nucleotide sequence comprising a cleavage site and (b) a detectable label; and in some aspects, is a cleavable nucleotide sequence with a detectable label and a non-reactive nucleotide sequence or a primer nucleotide sequence.

Arrays with quality control tracers

A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.

Flow cell package and method for making the same

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San Diego, CA, United States of America

Naiqian Zhan