Piramal Enterprises Limited

Piramal Pharma Limited

Nainesh Kansagara

Milind Moreshwar Gharpure

Ashutosh Jagtap

Changdev Raut

Navnath Patil

Sanjay Kumar Sharma

Jaisankar Krishnapillai

Nirmal Kumar Manoharan

The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (h) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.

Process for the preparation of droxidopa and its intermediate

The present invention provides an improved process for preparation of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; commonly known as vortioxetine (referred to as the compound (I)) and pharmaceutically acceptable salts thereof; wherein the process comprises reaction of 2-((2,4-dimethylphenyl)thio)aniline (II) with bis(2-alkyl)amine (IIIa) or its salt in the presence of a cyclic amide solvent.

Process for the preparation of vortioxetine and salts thereof

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Mumbai, India

Nainesh Kansagara