Council of Scientific and Industrial Research

Naibedya Chattopadhyay

Girish Kumar Jain

Ritu Trivedi

Abhishek Kumar Singh

Rakesh Maurya

Anil Kumar Dwivedi

Sabyasachi Sanyal

Divya Singh

Srikanta Kumar Rath

Avinash Kumar

Anil Kumar Tripathi

Lakshmi Manickavasagam

Harish Kumar

Amit Kumar

Man Mohan Singh

Atul Goel

Atul Kumar

Prabhat Ranjan Mishra

Varsha Gupta

Arun Kumar Trivedi

Nidhi Singh

Sumit Chaurasia

Vikram Khedgikar

Anagha Gurjar

Jiaur Rahaman Gayen

Jyoti Gautam

Kamal Ram Arya

Ravishankar Ramachandran

Riyazuddin Mohammed

Shailendra Kumar Dhar Dwivedi

Sourav Chattopadhyay

Manisha Yadav

Bandana Chakravarti

Sapana Kushwaha

Jay Sharan Mishra

Shikha Dubey

Kiran Lata

Abnish Kumar Gautam

Rashmi Pandey

Preeti Rawat

Kunal Sharan

Shelendra Pratap Singh

Jawed Akhtar Siddiqui

Preety Dixit

Gaurav Swarnkar

Wahajuddin

Geetanjali Mishra

Girish Kumar Gupta

Kamini Srivastava

Arun Kumarv Trivedi

Jawahar Lal

Dipak Datta

Sonal Shree

Tahseen Akhtar

Smrati Bhadauria

Rashmi Kumari

Parvez Mohammad Khan

Kainat Khan

Devendra Pratap Mishra

Sharad Sharma

Ram Arya Kamal

Sheelendra Pratap Singh

The present invention relates to method of treating chronic myeloid leukemia (CML) or drug resistant CML comprising, administering to human being or any other mammal or animal in need thereof, a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition; or a combination of a therapeutically effective amount of Clofazimine (CFZ) or its pharmaceutically acceptable derivative, analogue, salt or composition with a tyrosine kinase inhibitor (TKI). The invention also provides the kit for treatment of CML or drug resistant CML.

Combination of clofazimine and imatinib for effective therapy of drug-resistant myeloid leukemia

The present invention relates to bioactive fractions and compounds fromfor the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, fromplant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.

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The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof. 

Aryl naphthyl methanone oxime(s) and process for preparation thereof

The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R, R, R, R, R, R, R, Rare independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein RRor RRor RRmay be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C&#x2014;OH, C-Me, C&#x2014;OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders. 

Substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders

The present invention provides a flavonol compound and a bioactive extract/fraction fromuseful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R&#x2550;R&#x2550;OH K012: R&#x2550;R&#x2550;OH, 2,3 double bond K068: R&#x2550;R&#x2550;H KIOOi R&#x2550;OH, R&#x2550;H mula 2 Wherein the marker compounds K012, K058, K068, K1OO ranges 6.7-12%, 1.7-4.5%, 0.6-1.2%, 1.7-4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route. 

The present invention relates to a microcapsule for controlled release of flavanoid compound and a process for preparation thereof. The microcapsule comprising a core particle consisting of a calcium salt, Pluronic F68 [poly (ethylene oxide-co-polypropylene oxide), block poly oxyethylene-polypropylene block copolymer], loaded with a flavanoid compound, the resulting core particle having a plurality of alternate layers of cationic and anionic polyelectrolytes adsorbed thereon and an outer layer formed by a bile salt, wherein the flavanoid is ranging between 10 to 96% by weight.

Controlled release micro-capsule for osteogenic action

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Lucknow, India

Naibedya Chattopadhyay