Corum Inc.

Sunny Pharmtech Inc.

Nai-Hsuan Hsu

Chu-Yi Pang

Wei-Chuan Tsai

Chen-Yin Chen

Ming-Yi Chiu

Yi-Fan Ling

Chia-Jung Hsu

Jien-Heh Tien

Ssu-Ching Wang

Chi-Jen Huang

Chiao-Yi Hsu

Ting-Wan Chen

Chien-Jen Wu

Peimin Lee

A process for preparing azelaic acid is disclosed. In particular, the process for preparing azelaic acid is an ozone free process. The process for preparing azelaic acid comprises a step of decarboxylation of tetra-carboxylic acid in the presence of a organic sulfonic acid.

Process for preparing azelaic acid

This invention discloses a method of making vitamin K1. The mentioned method of making vitamin K1 comprises performing a first one-pot synthesis with base catalyst, performing a first hydrolysis, performing a substitution, and performing a second one-pot synthesis without metal oxidant. The starting material of this invention is stable 2-methyl-1,4-naphthoquinone. Preferably, this invention provides a method of making vitamin K1 efficiently on simplifying the operation and decreasing the side-product. More preferably, without metal residue, the vitamin K1 of this invention is without metal residue and more safety for clinical application.

Method of making vitamin K1

This invention discloses novel crystalline polymorphs of acetyl-glycine-beta-alanine and process of making the same. The mentioned crystalline polymorphs can exhibit excellent purity and storage stability according to this invention. Therefore, the mentioned crystalline polymorphs can be applied in topical cosmetic compositions, pharmaceutical compositions as skin care preparations, or other functional preparations.

Crystalline polymorphs of acetyl-glycine-beta-alanine and process of making the same

The invention provides a method for inhibiting melanin formation composition by applying a glycine derivative, having a structure shown in the following general equation (I): wherein Rrepresents a C1&#x2dc;C4 alkyl group; Rrepresents a hydrogen atom or a methyl group; and n represents an integer of 1&#x2dc;6.

Glycine derivative capable of inhibiting melanin formation and composition using the same

The present invention discloses compounds with a carboxyl acid group and an amide group which also containing the tertiary amino groups. The carboxyl acid group having a partial negative charge can attract the tertiary amino group with each other to form a quaternary ammonium salt structure, so that the compounds are easy to dissolve in water. Moreover, these compounds having a mushroom tyrosinase-inhibition effect and have the potential to use in the cosmetics for skin whitening.

Compound with carboxyl acid group and amide group and application thereof

A process for synthesis of androstane 17-&#x3b2; carbothioic acid is provided. The process includes mixing an androstane 17-&#x3b2; carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-&#x3b2; carbothioic acid, wherein the androstane 17-&#x3b2; carbothioic acid has the formula (I): 

Process for synthesis of androstane 17-&#x3b2; carbothioic acid and relative compounds thereof

The present invention discloses the ascorbic acid derivatives. The inventive molecules that combine with one or two hydrophilic headgroups connected by a hydrophobic spacer can increase skin penetration.

Growing community of inventors

Taipei, Taiwan

Nai-Hsuan Hsu