Council of Scientific and Industrial Research

Nahid Ali

Santu Bandyopadhyay

Siddhartha Roy

Aditya Konar

Balaram Ghosh

Bikas Chandra Pal

Bholanath Paul

Parasuraman Jaisankar

Jayaraman Vinayagam

Indrani Choudhury Mukherjee

Sanjit Kumar Mahato

Anirban Manna

Manjarika De

Sushovan Chowdhury

Deba Prasad Jana

Pradyot Bhattacharya

Roma Sinha

Jaydeep Chaudhuri

Jayashree Bagchi Chakraborty

Arun Bandopadhyay

Ulaganathan Mabalirajan

Arjun Ram

Triparna Sen

Jayachree Bagchi Chakrabotry

The present disclosure relates to the synergistic liposomal formulation comprising, phophatidylcholine, stearylamine and anticancer drugs for the treatment of cancer. The PC:SA cationic liposome encapsulated camptothecin (CPT) and doxorubicin (DOX) formulations show enhanced synergistic anti-cancer effect and provide improved therapeutic index as compared to either the liposome or drug alone. The present disclosure also relates to the use of Cationic liposomal preparation of phosphatidylcholine:stearylamine (PC:SA) showing anticancer effect. The SA-bearing liposome and drug entrapped in the liposome are effective against cancer both in vitro and in vivo, without causing any adverse effect on host.

Synergistic liposomal formulation for the treatment of cancer

The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma

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Jadavpur, India

Nahid Ali