Apotex Pharmachem Inc.

Nageib Mohamed

Bhaskar Reddy Guntoori

Eckardt C G Wolf

Gamini Weeratunga

Allan W Rey

Yajun Zhao

Cameron L McPhail

Sammy Chris Duncan

Peter Garth Blazecka

Randa E El-Haj

Provided for in the instant application are two additional forms of rifaximin, namely rifaximin polymorphic forms APO-III and APO-IV. Also provided are allegedly novel processes for preparing the previously disclosed rifaximin polymorphic forms APO-I and APO-II. Rifaximin is a non-aminoglycoside antibiotic that has previously been found to be useful for the treatment of traveller's diarrhea caused bybacteria, as well as in the treatment of irritable bowel syndrome, diverticular disease, hepatic encephalopathy, pyogenic skin infections and as an antibacterial prophylactic prior to colon surgery.

Polymorphic forms of rifaximin

The present invention provides a novel and improved process for the preparation of Zonisamide and the intermediates thereof. In one aspect of the present invention, the process provides for: the preparation and isolation of a novel crystalline form of anhydrous 1,2-benzisoxazole-3-methanesulfonic acid of formula 1; the direct chlorination of the acid of formula 1 into its acid chloride of formula 2; and the in situ conversion of the intermediate acid chloride of formula 2 into Zonisamide 

Process for the preparation of zonisamide and the intermediates thereof

A process for the preparation of Balsalazide and its pharmaceutically acceptable salts wherein the reaction comprises:

Safe process for the preparation of balsalazide

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Oakville, Canada

Nageib Mohamed