University of Illinois

Celanese Eva Performance Polymers Corporation

Nagarjuna Palyam

Stephen J Davis

Kaitlyn C Gray

Martin D Burke

Stephen Scott Davis

David M Knapp

Justin Robert Struble

Ian Dailey

Brice E Uno

Pulin Wang

Jeffrey Charles Haley

Christian Schneider

Chelsea Ringham

Justin Struble

Stephen Davis

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Amphotericin B derivatives with improved therapeutic index

A polymer composition that comprises an olefinic polymer, a flame retardant that includes a halogen-free mineral filler, and a compatibilizing agent is provided. The halogen-free mineral filler constitutes from about 20 wt. % to about 80 wt. % of the composition. The composition may exhibit a degree of water uptake of about 5 wt. % or less after being immersed in water for seven days at a temperature of 23&#xb0; C.

Polymer composition for use in cables

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3' or C4&#x2032; modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

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Florence, KY, United States of America

Nagarjuna Palyam