Global Life Sciences Solutions USA LLC

Cytiva Sweden Ab

Nagaraju Konduru

Prashanth Hosabettu Mohan

Sandip Maity

Manoj Kumar Ramakrishna

Nagapriya Kavoori Sethumadhavan

Andreas Castan

Haresh Digambar Patil

Swapnil Puranik

Harsha Aeron

Li Ou

Krishna Kumar Swaminathan

Sridhar Dasaratha

Sittal George

Mithilesh Mohanty

Vinay Bhaskar Jammu

Alok Singh Chauhan

Neelima Boddapati

Ankita Bhatia

The present invention relates to a method for predicting outcome of a process used for manufacturing a sample in a bioreactor, the process belonging to a category. The method comprises selecting () a process model based on the category; accessing () historic data related to past process runs for manufacturing the sample; accessing () current data obtained () from a current process run of the process. The obtained current data, which is based on the selected process model, comprises: process strategy data, bioreactor instrument data, data from online sensors and/or data from offline sensors. The method further comprises predicting () an outcome of at least one selected parameter of the current process run for manufacturing the sample based on the accessed historic data and current data. The present invention also relates to a method for modelling a process and a control system () for controlling a process.

Method for predicting outcome of an modelling of a process in a bioreactor

Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.

Apparatus and methods for adjustable volume cell culture

A microfluidic device () is disclosed for in-process monitoring of cell culture conditions including for example one or more of: cell density; cell viability; secreted proteins; protein analysis; epitope markers; concentrations of metabolites or nutrients and antigenic determinations; the device comprising: a cell inlet path (); plural fluid reservoirs () in fluid communication with the cell input path, a cell analysis area () in fluid communication with the path and reservoirs, and a waste storage volume () also in fluid communication with the cell analysis area, the device being operable to cause a primary fluid flow along the inlet path to the analysis area, and to selectively cause secondary fluid flow(s) into the path from none, one or more of the selected reservoirs to combine, if one or more of the reservoirs are selected, with the primary fluid flow from the cell inlet path, in each case for analysis at the cell analysis area, the device being further operable to cause a fluid flow of the primary and any combined secondary flows from the cell analysis area into the waste storage volume.

Microfluidic device for cell culture monitoring

Growing community of inventors

Bengaluru, India

Nagaraju Konduru