Novartis Ag

University of Minnesota

Other

International Business Machines Corporation

Microtherm LLC

Nanometrics Inc.

Nagaraja P Rao

Peter H McMurry

Jeffry G Weers

Daniel Huang

William W Alston

John Paul Palmer-Felgate

George S Axford

Danforth Miller

Mark Glusker

David Selby Maltz

Steven L Girshick

Keith Ung

Mark Postich

Jonathan Wilkins

Joachim V Heberlein

Neeraj Pakala

Willard R Foss

Thomas E Tarara

David B Kittelson

Aziz M Ahsan

William W Gerberich

Trixie Tan

Kianoush Beyzavi

Paul J Ziemann

Peng Liu

Patrick D Kinney

George Axford

Neeraf Pakala

Embodiments of the invention relate to particulate agents and compositions comprising particulate agents for inhalation, and methods for preparing such particulate agents and compositions for inhalation, as well as therapeutic methods. Embodiments of the method comprise preparing an emulsion by combining an oil phase dispersion of hydrophobic seed particles and an aqueous dispersion comprising an emulsifier and an emulsion stabilizer and preparing a feedstock comprising encapsulated particles by homogenizing the emulsion, and forming a plurality of coated particles by spray drying the feedstock, wherein resulting particles comprises a porous shell disposed on or over a core and the core comprises at least one hydrophobic seed particle.

Spray-dried solid-in-oil-in-water dispersions for inhalation of active pharmaceutical ingredients

Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing, mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.

Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices

Dry powder formulations for inhalation comprising spray-dried particles and their use in the treatment of an obstructive or inflammatory airways disease. Each particle has a core of a first active ingredient in substantially crystalline form that is coated with a layer of a second active ingredient in substantially amorphous form that is dispersed in a pharmaceutically acceptable hydrophobic excipient. A process for preparing such formulations is also described.

Dry powder formulations of particles that contain two or more active ingredients for treating obstructive or inflammatory airways diseases

Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.

A particle beam deposition apparatus includes a particle source for generating a plurality of particles in suspended form, an expansion chamber, and a deposition chamber connected to the expansion chamber by an aerodynamic focusing stage, and containing a substrate. The aerodynamic focusing stage may be comprised of a plurality of aerodynamic focusing elements, or lenses. Particles, including nanoparticles, may be deposited on the substrate by generating an aerosol cloud of particles, accelerating the particles into the expansion chamber, creating a collimated beam out of the particles by passing them through the aerodynamic focusing lenses and into a deposition chamber, and impacting the particles into the substrate.

Apparatus and method for synthesizing films and coatings by focused particle beam deposition

An optical inspection module detects defects on an active surface of a substrate in an integrated process tool system. The optical inspection module includes an enclosure, a substrate holder, a light source, a light beam path, a lens and a photodetector array. The light source has a light beam port. The light beam path extends from the light beam port to the substrate holder and has a grazing angle of incidence with respect to the active surface of the substrate. The light beam path illuminates substantially the entire active surface. The lens is oriented to collect non-secularly reflected light scattered from the light beam path by any defects on the active surface. The photodetector array has a plurality of pixels which are positioned within a focal plane of the lens. Each pixel corresponds to an area on the active surface, and the plurality of pixels together form a field of view that covers substantially the entire active surface.

Optical inspection module and method for detecting particles and defects

A method and apparatus for the controlled synthesis and assembly of nanoparticles into nanostructured materials, including nanocomposites, includes a source of nanoparticles and a hypersonic impaction apparatus. The nanoparticles are impacted on a substrate through hypersonic impaction to thereby provide nanostructured materials as well as nanophase materials.

Production of nanostructured materials by hypersonic plasma particle

The present invention relates generally to a new apparatus and a method for a high-efficiency in-situ vacuum particle detection. More particularly, the invention encompasses an apparatus for a particle detecting instrument designed to detect the presence of gas-borne particles in a vacuum line with high efficiency, using a sharply converging nozzle to preferentially focus the suspended particles flowing through it into a small region located on the nozzle axis within a few exit dimensions downstream from the nozzle exit. This focal region has a dimension much smaller than that of the nozzle exit, and is illuminated by a narrow, intense light beam. The particles passing through the illuminated focal region are detected by photodetector elements receiving light scattered from the particles. A method and an apparatus for high-efficiency, in-situ particle separation and/or measurement is also disclosed.

Apparatus and method for high-efficiency, in-situ particle detection

A particle beam shaping apparatus preferably includes a prefocusing element and a primary focusing element disposed within a tube. An aerosol beam source having relatively heavy particles and relatively light gas is operably connected to the prefocusing element. The prefocusing element preferentially expands the aerosol beam such that the gas diverges laterally relatively rapidly while the particles diverge laterally relatively slowly. The tube laterally confines the rapidly expanding gas such that the primary focusing element converges the gas upon the particle beam to more narrow the particle beam. A detector may be located downstream of the primary focusing means to sense the particles impinging thereon. A skimmer is preferably interposed between the primary focusing element and the detection means to remove the gas while allowing the particles to pass therethrough. The particles may be electrically charged and deflected prior to their detection such that the particles' relative masses may be determined by the detection means.

Apparatus and method for shaping and detecting a particle beam

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Minneapolis, MN, United States of America

Nagaraja P Rao