Cytiva Sweden Ab

Nagaraj Raghavendra Rao

Klaus Gebauer

Colin R Tuohey

Ralph Stankowski

Richard Lee Damren

Jonathan A Kenney

Mats Olsson

Anindya Kanti De

Nirmal Kumar Thanikachalam

Anindya Sengupta

Thomas Falkman

Sahebagouda Alagur

Bineesh Kandoth

The present subject matter discloses a bioreactor apparatus. The bioreactor apparatus comprises a bioreactor vessel configured to culture cells. The bioreactor apparatus furthermore comprises a sensor configured to measure Dissolved Oxygen (DO) in the bioreactor vessel. The DO measurements comprise a plurality of DO values recorded at, at least, a plurality of time instances during operation of the bioreactor apparatus. The bioreactor apparatus furthermore comprises a controller configured to obtain the DO measurements. The controller furthermore is to determine, in real-time or approximately real-time, an oxygen mass transfer co-efficient (kLa) associated with the operation of the bioreactor apparatus. Furthermore, the controller is configured to control, in real-time or approximately real-time, at least one cell culture parameter associated with the operation of the bioreactor apparatus based on the kLa.

Bioreactor apparatus and operation method thereof

A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

Housing for holding a flexible bioprocess bag and method for assembling the bag in the housing

Housing for holding a flexible bioprocess bag

Growing community of inventors

Bengaluru, India

Nagaraj Raghavendra Rao