Acceleron Pharma Inc.

Naga Venkata Sai Rajasekhar Suragani

Ravindra Kumar

Jasbir S Seehra

John L Knopf

Asya Grinberg

Dianne S Sako

Robert Scott Pearsall

Pedro Martinez

John Knopf

In certain aspects, the present disclosure provides compositions and methods for increasing red blood cell and/or hemoglobin levels in a subject in need thereof. Subjects in need include, for example, subjects having anemia and/or ineffective erythropoiesis as a result of having reduced GATA-1, heat shock factor and/or NFE2 levels as compared to the levels in a reference population.

Methods for increasing red blood cell levels and treating ineffective erythropoiesis

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

Methods and compositions for increasing red blood cells

Methods and compositions using GDF15 polypeptides for increasing red blood cells

In part, the present disclosure relates methods for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or one or more complications of a myeloproliferative disorder. The present disclosure further relates methods for treating, preventing, or reducing the severity of a Janus kinase-associated disorder or one or more complications of a Janus kinase-associated disorder. In certain aspects the disclosure provides T&#x3b2;RII antagonists for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or a Janus kinase-associated disorder or one or more complications of a myeloproliferative disorder or a Janus kinase-associated disorder.

Methods for treating Janus kinase-associated disorders by administering soluble transforming growth factor beta type II receptor

Methods for increasing red blood cell levels comprising administering BMP9

Growing community of inventors

Norwood, MA, United States of America

Naga Venkata Sai Rajasekhar Suragani