The Texas A&M University System

Naga Venkata Ravi Kumar Majeti

Raghu Ganugula

Meenakshi Arora

Prabhjot Saini

Dianxiong Zou

The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) urolithin A. The disclosure also provides methods and pharmaceutical compositions comprising the nanoparticle compositions for use in treating patients with various disease states.

Compositions comprising urolithin a and uses thereof in treating kidney injury

A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CHClto create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CHCl:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CHCland then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.

Polymer/copolymer nanoparticles conjugated to gambogic acid

The present invention provides a biodegradable 'precision polymer system' (poly system) and methods for preparing pharmaceutically effective 'precision polymer nanosystems' (polymer nanosystem) for delivery and/or targeting of drugs or drug like compounds.

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College Station, TX, United States of America

Naga Venkata Ravi Kumar Majeti