Astrazeneca Ab

Bayer Pharma Aktiengesellschaft

Bayer Schering Pharma Ag

Nafizal Hossain

Martin Hemmerling

Stinabritt Nilsson

Hartmut Rehwinkel

Markus Berger

Anders Eriksson

Karl Henrik Edman

Thomas Hansson

Per Tomas Klingstedt

Stephen Connolly

Matti Juhani Lepistö

Svetlana Ivanova

Grigorios Nikitidis

Lena Elisabeth Ripa

Igor Shamovsky

Anna Kristoffersson

Johan Rune Michael Lundkvist

Susanne Elisabeth Berglund

Jan Dahmen

Jan Dahmén

Marguerite Mensonides-Harsema

Andrew Baxter

Matti Juhani Lepisto

Austen Pimm

James Reuberson

Jörgen Gustafsson

The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).

Chemical compounds

The present invention provides a compound of a formula (I): 

The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD). 

A compound of formula Ia:  The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.

Phenyl and benzodioxinyl substituted indazoles derivatives

A compound of formula Ia:  The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments

The invention provides compounds of formula (I) wherein m, R, n, R, q, p, X, Y, R, R, t and, Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Tricyclic spiroderivatives as modulators of chemokine receptor activity

The invention provides compounds of formula (I) wherein m, R, n, R, q, X, Y, Z, t, R, R, R, R, Rand Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. 

Compounds

The invention provides compounds of formula (I)  wherein m R, n, R, q, X, Y, Z, R, R, R, R, R, R, t, and Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Tricyclic spiropiperidines or spiropyrrolidines

The invention provides compounds of general formula (I), in which m, n, Z, Z, R, R, R, Rand Rare as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; and their use in therapy 

Growing community of inventors

Lund, Sweden

Nafizal Hossain