Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Naeem Khan

Peter H Seeberger

Claney Lebev Pereira

Chakkumkal Anish

Marilda Lisboa

Madhu Emmadi

Christopher Martin

Sharavathi Guddehalli Parameswarappa

Benjamin Schumann

Lennart Lykke

Fei-Fei Xu

Adam Calow

Paulina Kaplonek

Petra Menova

Guozhi Xiao

The present invention relates to immunogenic compositions comprising a conjugate of a saccharide fromserotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides fromserotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRMcarrier protein, or a mixture consisting of capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide fromserotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide fromserotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by

Pneumococcal polysaccharide-protein conjugate composition

The present invention relates to a synthetic saccharide of general formula (I) that is related toserotype 2 capsular polysaccharide, a conjugate thereof and the use of said saccharide and conjugate for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies againsttype 2 bacteria.

Synthetic vaccines againstserotype 2

The present invention relates to synthetic saccharides of general formula (I): V*&#x2014;[U&#x2014;U&#x2014;U]&#x2014;V&#x2014;O-L-NHthat are related to carbapenem-resistantcapsular polysaccharide and conjugates thereof. Said conjugates and pharmaceutical composition containing said conjugates are useful for prevention and/or treatment of diseases associated with carbapenem-resistant. Furthermore, the synthetic saccharides of general formula (I): V*&#x2014;[U&#x2014;U&#x2014;U]&#x2014;V&#x2014;O-L-NHare useful as marker in immunological assays for detection of antibodies against carbapenem-resistantbacteria.

Vaccines against carbapenem-resistant

The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit ofserotype 5 capsular polysaccharide and conjugates thereof. The conjugates and pharmaceutical compositions containing said conjugates are useful for prevention and/or treatment of diseases associated with, and more specifically against diseases associated withserotype 5. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies againstbacteria. 

Vaccines againstserotype 5

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Berlin, Germany

Naeem Khan