The Scripps Research Institute

Mindera Corporation

Second Genome, Inc.

Nadir A Mahmood

Tahir Mahmood

Petr Capek

Tobin J Dickerson

Rachel Steger

Peter DiStefano

Tahir A Mahmood

The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

Methods and devices for detection and acquisition of biomarkers

The disclosure provides assay methods for characterizing the effects of an agent on a microbiome of a subject. Moreover, the disclosure provides methods for practical applications of assay results. The biological sample is extracted and the microbial population is enumerated by using signals or markers specific to the microbial species. The enumerated population is subjected to the action of one or many therapeutic agents and the efficiency is assessed by deriving a score based on the effects in the individual samples and in the population of samples.

Microbial ecology shift assay

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San Francisco, CA, United States of America

Nadir A Mahmood