Institut National De La Sante Et De La Recherche Medicale

Other

Bioprojet

Societe Civile Bioprojet

Societe Civile Bioproject

Nadine Noel

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Pierre Duhamel

Lucette Duhamel

Denis Danvy

Thierry Monteil

Claude Gros

Jean-Christophe Plaquevent

Olivier Chamard

Serge Piettre

Christophe Lusson

The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A(LTA), and enzyme which is responsible for the biosynthesis of leukotriene LTB, a major proinflammatory mediator. The invention also relates to therapeutic anti-inflammatory, applications of these compounds as well as for methods of preparing these compounds.

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The invention concerns compounds inhibiting LTAhydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.

LTA4 hydrolase inhibitors

The invention concerns LTA hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.

New amino acid derivatives, processes for their preparation, and their therapeutic application are described. These amino acid derivatives correspond to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.

Amino acid derivatives, processes for their preparation and their

New amino acid derivatives, processes for their preparation and their therapeutic application. Amino acid derivatives corresponding to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.

Amino acid, derivatives, processes for their preparation and their

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Moernach, France

Nadine Noel