Leland Stanford Junior University

Benaroya Research Institute at Virginia Mason

Nadine Nagy

Paul Laszlo Bollyky

Jayakumar Rajadas

Kevin Vincent Grimes

Thomas Wight

Hedwich F Kuipers

4-methylumbelliferone is useful for the treatment of autoimmune diseases, such as primary sclerosing cholangitis (PSC).

Methods of treatment using 4-methylumbelliferone and derivatives thereof

This disclosure presents 4-MUG derivatives (e.g., 4-MUG ester prodrugs) that reduce or prevent HA synthesis. In some embodiments, the 4-MUG derivatives of the present disclosure can be used to suppress HA synthesis and curtail inflammation.

4-methylumbelliferone derivatives for treatment for immune modulation

Compositions for treating autoimmune, allergic, or atopic disease comprising a compound that inhibits hyaluronan synthesis and a pharmaceutically acceptable carrier are described. In some embodiments, the compound that inhibits hyaluronan synthesis is 4-methylumbelliferone or a metabolite of 4-methylumbelliferone. Methods for treating autoimmune diabetes, multiple sclerosis and/or autoimmune demyelination, including administering to the subject a composition having a compound in an amount effective to inhibit hyaluronan synthesis in a mammalian subject, are also described.

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Palo Alto, CA, United States of America

Nadine Nagy